This metabolite includes a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately fifty% with the mother or father drug. Plasma concentrations of this metabolite are approximately 40% of Individuals found for sildenafil, so which the metabolite accounts for approximately twenty% of sildenafil's pharmacologic ef
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At doses previously mentioned the advisable dose selection, adverse reactions ended up comparable to those detailed in Table 1 down below but usually were noted more often.Medical data have proven that co-administration with saquinavir or erythromycin greater plasma levels of sildenafil by about three fold [see DRUG INTERACTIONS and Scientific PHAR